Metabolic reprogramming through precise nutrient modulation
Our groundbreaking research shows that by precisely modulating nutrients through diet, we can reprogram metabolism to significantly slow cancer growth and improve the efficacy of standard treatments.Read our research
Cancer-specific nutrient modulation slows tumor growth and increases survival time
Our preclinical research has shown that a serine and glycine restricted diet can significantly improve survival, doubling the 12-month survival rate in one model from 25% to 50%.
Data replicated in numerous other in vivo cancer models including mouse xenograft and allograft tumor models.
Apc min/+ and Eμ-Myc genetically engineered mouse models of cancer
Diet change implemented after tumour initiation at 60-80 days of age (i.e. not from birth)
Intervention is diet only (i.e. without any additional therapeutic agent)
Maddocks et. al. (2017), Nature, 544, 372-376
Faeth dietary intervention makes a targeted therapy more than 500% more effective
Faeth is designed to help create a foundation for many other treatments. In preclinical models, when paired with Faeth, other treatments are as much as 500% more effective.
Pancreatic Cancer In Vivo Model
Syngeneic allograft tumours with mutant Kras & mutant p53
Hopkins et. al. (2018), Nature, 560, 499-503
Validated in over 10 in vivo cancer models with multiple PI3K inhibitors.
Faeth makes standard treatments more effective and optimizes nutrition
When precise control of nutrition levels is combined with existing treatments, our preclinical research has shown we can stop cancer in its tracks.
Pancreatic cancer and normal pancreas tissue organoids derived from multiple human subjects and grown in vitro
NEAAR = Non-essential amino acid restriction (removal of selected non-essential amino acids from growth medium)
Gem-Pac = Gemcitabine and paclitaxel
Every cancer, every patient
We are on a mission to develop treatments for every cancer, every patient. MetabOS is our discovery platform that combines machine learning and the metabolic genome to uncover new metabolic treatments for cancer.